Dott. Paderni, Prof.ssa Macedi, Prof. Formica, Prof. Giorgi, Prof. Fusi, Prof. Fanelli
Abstract
Malten and Maltonis, prompted us to study the Pd2+ complexes of these latter from both a biological and metalloreceptor point of view. The Malten-Pd2+ complex can lodge hard species such as Sr2+ in its coordination-driven preorganized pocket, as confirmed by X-ray diffraction. UV–Vis and NMR data showed that Malten-Pd2+ forms even at acidic pH and exists in aqueous solution in a wide range of pH. The mononuclear complex is stable enough not to release Pd2+ in solution for a long period of time (at least one week), thus Malten-Pd2+, similarly to Maltonis-Pd2+, is suitable to be tested in biological analyses. Studies on the U937 cell line revealed that the effect on cell survival reduction induced by Malten is partially lost in Malten-Pd2+, while no differences where monitored between the effects of Maltonis-Pd2+ and Maltonis, suggesting that the availability of free maltol moieties, that is retained in Maltonis-Pd2+, but not in Malten-Pd2+, is crucial to guarantee the biological activity of these compounds.
Keyword
Antineoplastic activity Palladium(II) complex Maltol Metallo-receptors Macrocycles Polyamines
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