{"id":256893,"date":"2024-12-10T04:49:21","date_gmt":"2024-12-10T04:49:21","guid":{"rendered":"https:\/\/project.uniurb.it\/vitality\/?page_id=256893"},"modified":"2026-03-06T16:07:22","modified_gmt":"2026-03-06T16:07:22","slug":"wp1","status":"publish","type":"page","link":"https:\/\/project.uniurb.it\/vitality\/wp1\/","title":{"rendered":"WP1"},"content":{"rendered":"

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MISSIONE 4 \u2014 ISTRUZIONE E RICERCA <\/strong>| PNRR PER LA M4C2 INVESTIMENTO 1.5
CODICE IDENTIFICATIVO: ECS_00000041<\/strong> | CUP: H33C22000430006<\/strong><\/p>\n

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Innovative Therapeutic Approaches: New Chemical Entities, Biologics and Drugs Delivery<\/h1>\n

SPOKE 8 \u2014 PNRR MISSIONE 4<\/h3>\n

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Sviluppo di una piattaforma abilitante accessibile a terzi per la scoperta preclinica efficiente di farmaci \u2014 WP1 (M65)<\/span><\/h3>\n

L’obiettivo del WP1 \u00e8 consentire la produzione di candidati farmaci ottimizzati a un ritmo accelerato. Questo obiettivo chiave sar\u00e0 raggiunto attraverso compiti interconnessi:<\/p>\n

a) la creazione di una piattaforma appositamente concepita per l’identificazione di nuovi candidati farmaci attraverso un ciclo virtuoso di progettazione-sintesi-test. L’efficienza (ossia, non puntiamo a sintetizzare\/testare un gran numero di composti, ma a lavorare solo con quelli giusti) sar\u00e0 garantita da strumenti simulativi all’avanguardia basati sulla fisica e sull’intelligenza artificiale, che includono lo screening virtuale di librerie ultra-ampie, paradigmi sintetici avanzati come la tecnologia di flusso e l’automazione, saggi su linee cellulari multiple e modelli di organoidi, nonch\u00e9 previsioni di epatotossicologia basate sulla lipidomica;<\/p>\n

b) l’adozione dell’approccio ormai consolidato dei ligandi a bersagli multipli (“multitarget-directed ligand”), ovvero l’ingegnerizzazione razionale dell’attivit\u00e0 su bersagli multipli, come strategia per sfruttare rapidamente le conoscenze utili derivanti dall’analisi dei dati genomici e delle cartelle cliniche elettroniche;<\/p>\n

c) la valorizzazione della nostra conoscenza dei percorsi metabolici specifici e delle patologie (ad esempio, lo stress ossidativo nel cancro, la dipendenza da nicotina, ecc.) per ottimizzare l’identificazione di nuovi composti.<\/p>\n

Di conseguenza, il WP1 non solo generer\u00e0 valore attraverso nuove molecole, ma contribuir\u00e0 anche a validare e ridurre il rischio legato a nuovi bersagli e combinazioni di bersagli. Esiste un chiaro potenziale di sinergia con le attivit\u00e0 svolte nel WP2 (ad esempio, coniugati farmaco-anticorpo) e nel WP3 (somministrazione di farmaci).<\/p>\n

Nel complesso, il valore di questa iniziativa \u00e8 duplice: da un lato, generare propriet\u00e0 intellettuale (IP) attraverso nuove molecole, con la possibilit\u00e0 di creare spin-off, attrarre investimenti e concedere in licenza brevetti; dall’altro, promuovere partenariati con entit\u00e0 commerciali interessate a utilizzare la nostra piattaforma per sviluppare i propri progetti.<\/p>\n

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Persone<\/h3>\n

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Pubblicazioni\u00a0<\/h3>\n

[\/et_pb_text][et_pb_blog fullwidth=”off” posts_number=”25″ include_categories=”19″ show_more=”on” show_author=”off” show_date=”off” show_categories=”off” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_blog][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Eventi” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Eventi<\/h3>\n

[\/et_pb_text][et_pb_blog fullwidth=”off” posts_number=”25″ include_categories=”24″ show_more=”on” show_author=”off” show_categories=”off” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_blog][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

MISSIONE 4 \u2014 ISTRUZIONE E RICERCA | PNRR PER LA M4C2 INVESTIMENTO 1.5CODICE IDENTIFICATIVO: ECS_00000041 | CUP: H33C22000430006Innovative Therapeutic Approaches: New Chemical Entities, Biologics and Drugs Delivery SPOKE 8 \u2014 PNRR MISSIONE 4Sviluppo di una piattaforma abilitante accessibile a terzi per la scoperta preclinica efficiente di farmaci \u2014 WP1 (M65) L’obiettivo del WP1 \u00e8 consentire […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-256893","page","type-page","status-publish","hentry"],"yoast_head":"\nWP1 - Vitality<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/project.uniurb.it\/vitality\/wp1\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"WP1 - 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