{"id":257084,"date":"2025-07-28T09:53:06","date_gmt":"2025-07-28T09:53:06","guid":{"rendered":"https:\/\/project.uniurb.it\/vitality\/?p=257084"},"modified":"2025-10-08T08:59:37","modified_gmt":"2025-10-08T08:59:37","slug":"the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls","status":"publish","type":"post","link":"https:\/\/project.uniurb.it\/vitality\/the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls\/","title":{"rendered":"The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;2px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;50px|||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;16px&#8221; custom_margin=&#8221;||60px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">Dott. Andrea Di Credico, Dott.ssa Giulia Gaggi, Dott.ssa Ines Bucci, Dott.ssa Barbara Ghinassi, Dott.ssa Angela Di Baldassarre<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Abstract<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">The present study investigates the impact of two endocrine disruptors, namely Bisphenols (BPs) and Perfluoroalkyls (PFs), on human stem cells. These chemicals leach from plastic, and when ingested through contaminated food and water, they interfere with endogenous hormone signaling, causing various diseases. While the ability of BPs and PFs to cross the placental barrier and accumulate in fetal serum has been documented, the exact consequences for human development require further elucidation. The present research work explored the effects of combined exposure to BPs (BPA or BPS) and PFs (PFOS and PFOA) on human placenta (fetal membrane mesenchymal stromal cells, hFM-MSCs) and amniotic fluid (hAFSCs)-derived stem cells. The effects of the xenobiotics were assessed by analyzing cell proliferation, mitochondrial functionality, and the expression of genes involved in pluripotency and epigenetic regulation, which are crucial for early human development. Our findings demonstrate that antenatal exposure to BPs and\/or PFs may alter the biological characteristics of perinatal stem cells and fetal epigenome, with potential implications for health outcomes at birth and in adulthood. Further research is necessary to comprehend the full extent of these effects and their long-term consequences.<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px|||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Keyword<\/h4>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">Bisphenol A (BPA); Bisphenol S (BPS); perfluorooctane sulfonate (PFOS); perfluorooctanoic acid (PFOA); endocrine disruptors; perinatal stem cells; plastic pollutants; fetal membrane mesenchymal stromal cells (hFM-MSCs); amniotic fluid stem cells (hAFSCs)<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px|||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Link<\/h4>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dott. Andrea Di Credico, Dott.ssa Giulia Gaggi, Dott.ssa Ines Bucci, Dott.ssa Barbara Ghinassi, Dott.ssa Angela Di BaldassarreAbstractThe present study investigates the impact of two endocrine disruptors, namely Bisphenols (BPs) and Perfluoroalkyls (PFs), on human stem cells. These chemicals leach from plastic, and when ingested through contaminated food and water, they interfere with endogenous hormone signaling, [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21],"tags":[56,48,49,52,55,50,51,53,54],"class_list":["post-257084","post","type-post","status-publish","format-standard","hentry","category-wp3","tag-amniotic-fluid-stem-cells-hafscs","tag-bisphenol-a-bpa","tag-bisphenol-s-bps","tag-endocrine-disruptors","tag-fetal-membrane-mesenchymal-stromal-cells-hfm-mscs","tag-perfluorooctane-sulfonate-pfos","tag-perfluorooctanoic-acid-pfoa","tag-perinatal-stem-cells","tag-plastic-pollutants"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes - Vitality<\/title>\n<meta name=\"description\" content=\"Combined exposure to bisphenols and perfluoroalkyls alters perinatal stem cells and fetal epigenome, impacting health outcomes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/project.uniurb.it\/vitality\/the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes - Vitality\" \/>\n<meta property=\"og:description\" content=\"Combined exposure to bisphenols and perfluoroalkyls alters perinatal stem cells and fetal epigenome, impacting health outcomes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/project.uniurb.it\/vitality\/the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls\/\" \/>\n<meta property=\"og:site_name\" content=\"Vitality\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-28T09:53:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-08T08:59:37+00:00\" \/>\n<meta name=\"author\" content=\"Sofia Fiorentini\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sofia Fiorentini\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls\/\"},\"author\":{\"name\":\"Sofia Fiorentini\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#\/schema\/person\/6bf3aef708bc5fae080796827fec93b1\"},\"headline\":\"The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes\",\"datePublished\":\"2025-07-28T09:53:06+00:00\",\"dateModified\":\"2025-10-08T08:59:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls\/\"},\"wordCount\":441,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#organization\"},\"keywords\":[\"amniotic fluid stem cells (hAFSCs)\",\"Bisphenol A (BPA)\",\"Bisphenol S (BPS)\",\"endocrine disruptors\",\"fetal membrane mesenchymal stromal cells (hFM-MSCs)\",\"perfluorooctane sulfonate (PFOS)\",\"perfluorooctanoic acid (PFOA)\",\"perinatal stem cells\",\"plastic pollutants\"],\"articleSection\":[\"WP3\"],\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/project.uniurb.it\/vitality\/the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls\/\",\"url\":\"https:\/\/project.uniurb.it\/vitality\/the-effects-of-combined-exposure-to-bisphenols-and-perfluoroalkyls\/\",\"name\":\"The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes - 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