{"id":257327,"date":"2025-07-28T14:35:32","date_gmt":"2025-07-28T14:35:32","guid":{"rendered":"https:\/\/project.uniurb.it\/vitality\/?p=257327"},"modified":"2025-10-08T08:43:35","modified_gmt":"2025-10-08T08:43:35","slug":"easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids","status":"publish","type":"post","link":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/","title":{"rendered":"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;2px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;50px|||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;16px&#8221; custom_margin=&#8221;||60px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">Prof. Galluzzi, Prof. Favi, Dott. Giacomo Mari<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Abstract<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">A chemoselective one-pot synthesis of pharmaceutically prospective indole-pyrrole hybrids by the formal [3+2] cycloaddition of 3-cyanoacetyl indoles (CAIs) with 1,2-diaza-1,3-dienes (DDs) have been developed. The new indole-pyrrole hybrids were phenotypically screened for efficacy against Leishmania infantum promastigotes. The most active compounds 3c, 3d, and 3j showed IC50 &lt; 20 <span>\u03bcM<\/span> and moderate cytotoxicity, lower than miltefosine. Compound 3d was the most active with IC50 = 9.6 <span>\u03bcM<\/span> and a selectivity index of 5. Consequently, 3d could be a new lead compound for the generation of a new class of antileishmanial hybrids.<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px|||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Keyword<\/h4>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">Synthetic methodology, Organic chemistry<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;||0px|||&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>Link<\/h4>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; link_option_url_new_window=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"https:\/\/hdl.handle.net\/11576\/2737191\" target=\"_blank\" rel=\"noopener\" title=\"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents\">https:\/\/hdl.handle.net\/11576\/2737191<\/a>\u00a0<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prof. Galluzzi, Prof. Favi, Dott. Giacomo MariAbstractA chemoselective one-pot synthesis of pharmaceutically prospective indole-pyrrole hybrids by the formal [3+2] cycloaddition of 3-cyanoacetyl indoles (CAIs) with 1,2-diaza-1,3-dienes (DDs) have been developed. The new indole-pyrrole hybrids were phenotypically screened for efficacy against Leishmania infantum promastigotes. The most active compounds 3c, 3d, and 3j showed IC50 &lt; 20 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[19],"tags":[31,30],"class_list":["post-257327","post","type-post","status-publish","format-standard","hentry","category-wp1","tag-organic-chemistry","tag-synthetic-methodology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents - Vitality<\/title>\n<meta name=\"description\" content=\"One-pot synthesis of indole-pyrrole hybrids with antileishmanial activity; compound 3d shows IC\u2085\u2080 = 9.6 \u03bcM.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents - Vitality\" \/>\n<meta property=\"og:description\" content=\"One-pot synthesis of indole-pyrrole hybrids with antileishmanial activity; compound 3d shows IC\u2085\u2080 = 9.6 \u03bcM.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/\" \/>\n<meta property=\"og:site_name\" content=\"Vitality\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-28T14:35:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-08T08:43:35+00:00\" \/>\n<meta name=\"author\" content=\"Sofia Fiorentini\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sofia Fiorentini\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/\"},\"author\":{\"name\":\"Sofia Fiorentini\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#\/schema\/person\/6bf3aef708bc5fae080796827fec93b1\"},\"headline\":\"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents\",\"datePublished\":\"2025-07-28T14:35:32+00:00\",\"dateModified\":\"2025-10-08T08:43:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/\"},\"wordCount\":297,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#organization\"},\"keywords\":[\"Organic chemistry\",\"Synthetic methodology\"],\"articleSection\":[\"WP1\"],\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/\",\"url\":\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/\",\"name\":\"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents - Vitality\",\"isPartOf\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#website\"},\"datePublished\":\"2025-07-28T14:35:32+00:00\",\"dateModified\":\"2025-10-08T08:43:35+00:00\",\"description\":\"One-pot synthesis of indole-pyrrole hybrids with antileishmanial activity; compound 3d shows IC\u2085\u2080 = 9.6 \u03bcM.\",\"breadcrumb\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/project.uniurb.it\/vitality\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#website\",\"url\":\"https:\/\/project.uniurb.it\/vitality\/\",\"name\":\"Vitality\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/project.uniurb.it\/vitality\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#organization\",\"name\":\"Vitality\",\"url\":\"https:\/\/project.uniurb.it\/vitality\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/project.uniurb.it\/vitality\/wp-content\/uploads\/2023\/05\/vitality-pnrr-loghi.004.png\",\"contentUrl\":\"https:\/\/project.uniurb.it\/vitality\/wp-content\/uploads\/2023\/05\/vitality-pnrr-loghi.004.png\",\"width\":500,\"height\":200,\"caption\":\"Vitality\"},\"image\":{\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#\/schema\/person\/6bf3aef708bc5fae080796827fec93b1\",\"name\":\"Sofia Fiorentini\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/project.uniurb.it\/vitality\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/f1e160b1b056f68908e93e581241b50b9052714ce8f5b9890deb087631884a81?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/f1e160b1b056f68908e93e581241b50b9052714ce8f5b9890deb087631884a81?s=96&d=mm&r=g\",\"caption\":\"Sofia Fiorentini\"},\"sameAs\":[\"https:\/\/www.uniurb.it\"],\"url\":\"https:\/\/project.uniurb.it\/vitality\/author\/sofia-fiorentini\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents - Vitality","description":"One-pot synthesis of indole-pyrrole hybrids with antileishmanial activity; compound 3d shows IC\u2085\u2080 = 9.6 \u03bcM.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/","og_locale":"it_IT","og_type":"article","og_title":"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents - Vitality","og_description":"One-pot synthesis of indole-pyrrole hybrids with antileishmanial activity; compound 3d shows IC\u2085\u2080 = 9.6 \u03bcM.","og_url":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/","og_site_name":"Vitality","article_published_time":"2025-07-28T14:35:32+00:00","article_modified_time":"2025-10-08T08:43:35+00:00","author":"Sofia Fiorentini","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"Sofia Fiorentini","Tempo di lettura stimato":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/#article","isPartOf":{"@id":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/"},"author":{"name":"Sofia Fiorentini","@id":"https:\/\/project.uniurb.it\/vitality\/#\/schema\/person\/6bf3aef708bc5fae080796827fec93b1"},"headline":"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents","datePublished":"2025-07-28T14:35:32+00:00","dateModified":"2025-10-08T08:43:35+00:00","mainEntityOfPage":{"@id":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/"},"wordCount":297,"commentCount":0,"publisher":{"@id":"https:\/\/project.uniurb.it\/vitality\/#organization"},"keywords":["Organic chemistry","Synthetic methodology"],"articleSection":["WP1"],"inLanguage":"it-IT","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/","url":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/","name":"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents - Vitality","isPartOf":{"@id":"https:\/\/project.uniurb.it\/vitality\/#website"},"datePublished":"2025-07-28T14:35:32+00:00","dateModified":"2025-10-08T08:43:35+00:00","description":"One-pot synthesis of indole-pyrrole hybrids with antileishmanial activity; compound 3d shows IC\u2085\u2080 = 9.6 \u03bcM.","breadcrumb":{"@id":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/project.uniurb.it\/vitality\/easy-one-pot-synthesis-of-multifunctionalized-indole-pyrrole-hybrids\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/project.uniurb.it\/vitality\/"},{"@type":"ListItem","position":2,"name":"Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents"}]},{"@type":"WebSite","@id":"https:\/\/project.uniurb.it\/vitality\/#website","url":"https:\/\/project.uniurb.it\/vitality\/","name":"Vitality","description":"","publisher":{"@id":"https:\/\/project.uniurb.it\/vitality\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/project.uniurb.it\/vitality\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"},{"@type":"Organization","@id":"https:\/\/project.uniurb.it\/vitality\/#organization","name":"Vitality","url":"https:\/\/project.uniurb.it\/vitality\/","logo":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/project.uniurb.it\/vitality\/#\/schema\/logo\/image\/","url":"https:\/\/project.uniurb.it\/vitality\/wp-content\/uploads\/2023\/05\/vitality-pnrr-loghi.004.png","contentUrl":"https:\/\/project.uniurb.it\/vitality\/wp-content\/uploads\/2023\/05\/vitality-pnrr-loghi.004.png","width":500,"height":200,"caption":"Vitality"},"image":{"@id":"https:\/\/project.uniurb.it\/vitality\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/project.uniurb.it\/vitality\/#\/schema\/person\/6bf3aef708bc5fae080796827fec93b1","name":"Sofia Fiorentini","image":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/project.uniurb.it\/vitality\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/f1e160b1b056f68908e93e581241b50b9052714ce8f5b9890deb087631884a81?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/f1e160b1b056f68908e93e581241b50b9052714ce8f5b9890deb087631884a81?s=96&d=mm&r=g","caption":"Sofia Fiorentini"},"sameAs":["https:\/\/www.uniurb.it"],"url":"https:\/\/project.uniurb.it\/vitality\/author\/sofia-fiorentini\/"}]}},"_links":{"self":[{"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/posts\/257327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/comments?post=257327"}],"version-history":[{"count":3,"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/posts\/257327\/revisions"}],"predecessor-version":[{"id":257862,"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/posts\/257327\/revisions\/257862"}],"wp:attachment":[{"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/media?parent=257327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/categories?post=257327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/project.uniurb.it\/vitality\/wp-json\/wp\/v2\/tags?post=257327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}