[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”2px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”50px|||||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”16px” custom_margin=”||60px||false|false” global_colors_info=”{}”]<\/p>\n
Dott. Paderni, Prof.ssa Macedi, Prof. Formica, Prof. Giorgi, Prof. Fusi, Prof. Fanelli<\/span><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” locked=”on” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Malten and Maltonis, prompted us to study the Pd2+ complexes of these latter from both a biological and metalloreceptor point of view. The Malten-Pd2+ complex can lodge hard species such as Sr2+ in its coordination-driven\u00a0 preorganized pocket, as confirmed by X-ray diffraction. UV\u2013Vis and NMR data showed that Malten-Pd2+ forms\u00a0 even at acidic pH and exists in aqueous solution in a wide range of pH. The mononuclear complex is stable\u00a0 <\/span>enough not to release Pd2+ in solution for a long period of time (at least one week), thus Malten-Pd2+, similarly\u00a0 to Maltonis-Pd2+, is suitable to be tested in biological analyses. Studies on the U937 cell line revealed that the\u00a0 effect on cell survival reduction induced by Malten is partially lost in Malten-Pd2+, while no differences where\u00a0 monitored between the effects of Maltonis-Pd2+ and Maltonis, suggesting that the availability of free maltol\u00a0 moieties, that is retained in Maltonis-Pd2+, but not in Malten-Pd2+, is crucial to guarantee the biological activity\u00a0 of these compounds.<\/span><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||0px|||” locked=”on” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\nAbstract<\/h3>\n
Keyword<\/h4>\n