[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”2px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”50px|||||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”16px” custom_margin=”||40px||false|false” global_colors_info=”{}”]<\/p>\n
Front. Aging 7:1864375. | doi: 10.3389\/fragi.2026.1864375<\/span><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”16px” custom_margin=”||40px||false|false” global_colors_info=”{}”]<\/p>\n Francesca Monittola, Michela Bruschi, Sofia Masini, Domenico Pio Losito, Mauro Magnani, Luigia Rossi, Alessandra Fraternale and Rita Crinelli<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” locked=”on” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Lymph node architecture and function are markedly altered with aging. We previously demonstrated that the lymph nodes of old C57BL\/6 and BTBR male mice contain reduced levels of PA28\u03b1\u03b2-capped proteasomes compared to young mice. Here, we examined aged BTBR females relative to aged males and found that proteasome remodeling occurs in a sex-specific manner. Specifically, old female exhibited higher immunoproteasome activity than old male, despite similar levels of proteasome and immunoproteasome subunit expression and proteasome complex assembly. In female mice activity was mostly driven by PA28\u03b1\u03b2-capped 20S proteasomes that declined with age in males. These results highlight intriguing differences in proteasome assembly and activity between males and females providing evidence for sex-dependent changes in immunosenescence.<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||0px|||” locked=”on” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n aging, immunoproteasome, lymph nodes, PA28, sex<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||0px|||” locked=”on” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\nAbstract<\/h3>\n
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