CODICE IDENTIFICATIVO: ECS_00000041 | CUP: H33C22000430006
Innovative Therapeutic Approaches: New Chemical Entities, Biologics and Drugs Delivery
SPOKE 8 — PNRR MISSIONE 4
Sistemi avanzati di somministrazione di farmaci e strumenti teranostici in vivo per la medicina personalizzata — WP3 (M67)
L’obiettivo principale del WP3 è progettare strategie innovative per raggiungere terapie centrate sul paziente e personalizzate in base alle sue specifiche esigenze, in termini di efficacia, accuratezza, sicurezza e/o aderenza nella diagnosi e nel trattamento delle malattie.
A tal fine, saranno perseguiti tre obiettivi specifici:
a) Sviluppo di forme farmaceutiche personalizzate tramite tecnologie di produzione additiva (additive manufacturing);
b) Ingegnerizzazione di nanomedicine bioispirate e biomimetiche per una somministrazione precisa dei farmaci;
c) Ottimizzazione di metodi innovativi per il monitoraggio di tessuti e organi, basati su nanoparticelle di ossido di ferro cariche di farmaco (SPION), incorporate nei globuli rossi e guidate magneticamente, con tracciamento tramite Risonanza Magnetica (MRI) e Imaging di Particelle Magnetiche (MPI).
Persone
Luca Casettari
PO
Barbara Canonico
PA
Mariele Montanari
AdR - fino al 15/02/2025
Michele Guescini
PA
Piero Sestili
PO
Sonia Silvestri
AdR - fino al 01/11/2024
Francesca Lucchetti
PA
Luca Giorgi
PA
Luigia Rossi
PO
Annalisa Aluigi
PA
Rachele Agostini
AdR
Luca Mancini
AdR
Pubblicazioni
Management of Fibromyalgia: Novel Nutraceutical Therapies Beyond Traditional Pharmaceuticals
Prof. Giorgi, Dott.ssa Antonelli, Prof.ssa Bianchi, Prof.ssa RossiAbstractThe pathophysiology of fibromyalgia, a condition that causes chronic pain throughout the body, involves abnormal pain signaling, genetic predispositions, and abnormal neuroendocrine function,...
Leveraging machine learning to streamline the development of liposomal drug delivery systems
Prof. Luca Casettari, Dott. Mattia TiboniAbstractDrug delivery systems efficiently and safely administer therapeutic agents to specific body sites. Liposomes, spherical vesicles made of phospholipid bilayers, have become a powerful tool in this field, especially with...
Leveraging 3D-printed microfluidic micromixers for the continuous manufacture of melatonin loaded SNEDDS with enhanced antioxidant activity and skin permeability
Prof. Luca Casettari, Dott. Mattia TiboniAbstractVesicants are chemical warfare agents (CWAs) capable of causing severe skin damage and systemic toxicity. Melatonin, known for its anti-inflammatory and antioxidant properties, can mitigate the effects of these agents....
Efficient and highly reproducible production of red blood cell‑derived extracellular vesicle mimetics for the loading and delivery of RNA molecules
Prof.ssa Canonico, Dott. Tiboni, Dott.ssa Montanari, Prof Casettari, Prof Guescini, Prof.ssa Rossi, Prof MagnaniAbstractExtracellular vesicles (EVs) are promising natural nanocarriers for the delivery of therapeutic agents. As with any other kind of cell, red blood...
Exploring intranasal delivery of peptide and protein nanoparticles by a thermoresponsive hydrogel
Prof. Luca Casettari, Dott. Mattia TiboniAbstractEffective delivery of peptide or protein-based drugs (PPDs) remains a challenge as parenteral routes are invasive and PPDs are subjected to enzymatic degradation via the oral route. As such, intranasal (IN) route is an...
Combining innovation and sustainable development in the 3D printing manufacturing of drug delivery and testing devices
Prof. Luca Casettari, Dott. Mattia TiboniAbstractAdditive manufacturing (AM), commonly referred to as 3D printing (3DP), has made a significant impact on both manufacturing and healthcare, revolutionizing these industries. The key advantage of 3DP lies in rapid...
The dark side of the wool? From wool wastes to keratin microfilaments through the solution blow spinning process
Prof. Luca CasettariAbstractThe valorization of discarded wool from dairy sheep breeding is a challenging issue. The most proposed strategies lie in the processing of keratin extracted from wool without reducing the molecular weight of the protein chains (the high...
Non-invasive peptides delivery using chitosan nanoparticles assembled via calable microfluidic technology
Prof. Casettari, Dott. Tiboni, Prof.ssa AluigiAbstractThe delivery of peptides via non-invasive administration routes remains a challenge to be addressed. In this regard, chitosan nanoparticles (CS NPs) have shown promise. However, their current batch preparation...
Microfluidic development and biological evaluation of targeted therapy-loaded biomimetic nano system to improve the metastatic melanoma treatment
Prof. Luca Casettari, Dott. Mattia TiboniAbstractOptimizing current therapies is among next steps in metastatic melanoma (MM) treatment landscape. The innovation of this study is the design of production process by microfluidics of cell membrane (CM)-modified...
Biomimetic Platelet-Cloaked Nanoparticles for the Delivery of Anti-Inflammatory Curcumin in the Treatment of Atherosclerosis
Prof. Luca Casettari AbstractAtherosclerosis still represents a major driver of cardiovascular diseases worldwide. Together with accumulation of lipids in the plaque, inflammation is recognized as one of the key players in the formation and development of...
Super-Resolution-Chip: an in-vitro platform that enables super-resolution microscopy of co-cultures and 3D systems
Prof.ssa Rossana RautiAbstractThe development of organs-on-a-chip platforms has revolutionized in-vitro cellular culture by allowing cells to be grown in an environment that better mimics human physiology. However, there is still a challenge in integrating those...
Microfluidic manufacturing of tioconazole loaded keratin nanocarriers: Development and optimization by design of experiments
Dott Mattia Tiboni, Prof.ssa Annalisa Aluigi, Prof. Luca CasettariAbstractFungal infections of the skin, nails, and hair are a common health concern affecting a significant proportion of the population worldwide. The current treatment options include topical and...
Drug transport by red blood cells
Dott.ssa Sara Biagiotti, Dott.ssa Elena Pirla and Dott. Mauro MagnaniAbstractThis review focuses on the role of human red blood cells (RBCs) as drug carriers. First, a general introduction about RBC physiology is provided, followed by the presentation of several cases...
4D printed multipurpose smart implants for breast cancer management
Dott: Sofia Moroni, Prof. Luca CasettariAbstractBreast-conserving surgery (BCS) is the primary strategy for treating early-stage breast cancer; however, the incidence of local recurrence and breast tissue loss negatively impacts patients and survivors. Furthermore,...
3D printing fabrication of Ethylene-Vinyl Acetate (EVA) based intravaginal rings for antifungal therapy
Prof.ssa Annalisa Aluigi, Prof. Luca Casettari, Dott. Mattia TiboniAbstractThe present study investigates the impact of two endocrine disruptors, namely Bisphenols (BPs) and Perfluoroalkyls (PFs), on human stem cells. These chemicals leach from plastic, and when...
Assessment of the in-vitro toxicity and in-vivo therapeutic capabilities of Juglans regia on human prostate cancer and prostatic hyperplasia in rats
Dott: Azzurra Stefanucci, Lorenza Marinaccio, Eulogio J. Llorent-Martínez, Gokhan Zengin, Onur Bender, Rumeysa Dogan, Arzu Atalay, Omotayo Adegbite, Foluso O. Ojo, Adejoke Y. Onaolapo, Olakunle J. Onaolapo, Adriano MollicaAbstractBenign prostatic hyperplasia (BPH) and...
The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes
Dott. Andrea Di Credico, Dott.ssa Giulia Gaggi, Dott.ssa Ines Bucci, Dott.ssa Barbara Ghinassi, Dott.ssa Angela Di BaldassarreAbstractThe present study investigates the impact of two endocrine disruptors, namely Bisphenols (BPs) and Perfluoroalkyls (PFs), on human...
Eventi
Vitality Researchers’ Day – Presentazione delle attività di ricerca degli Spoke
Il VITALITY Researchers’ Day è la giornata conclusiva del ciclo di eventi dedicati allo stato di avanzamento delle attività di ricerca e innovazione del progetto VITALITY – finanziato dal PNRR M4C2, Investimento 1.5. L’incontro rappresenta un’occasione unica di...
Vitality Contamination Lab – Percorso di orientamento all’autoimprenditorialità
Il Contamination Lab è un percorso intensivo di orientamento e formazione rivolto ai partecipanti del PNRR Placement Program di VITALITY. Attraverso sei tappe full-immersion, i partecipanti saranno guidati passo dopo passo verso la creazione di una propria idea di...
Vitality Day – Avanzamenti scientifici e progetti dello Spoke 8
Un’intera giornata dedicata allo stato di avanzamento delle attività dello Spoke 8 del progetto VITALITY, finanziato dal PNRR – M4C2, Investimento 1.5. Il Vitality Day rappresenta un'occasione per conoscere i risultati delle ricerche in corso, i progetti selezionati...
One-Health: Personalized Nutrition and Physical Activity Interventions — Workshop interspoke – Progetto Vitality (Spoke 4 | Spoke 6)
Il workshop rappresenta un momento di confronto tra i gruppi di ricerca dell’Università di Urbino affiliati agli Spoke 4 (Università di Chieti) e Spoke 6 (Università di Camerino) del progetto VITALITY. Obiettivo principale dell’incontro è facilitare la condivisione di...
Young Scientists Meeting – Vitality (Spoke 8)
L'evento Young Scientists Meeting è un momento di confronto e valorizzazione delle giovani ricercatrici e dei giovani ricercatori coinvolti nelle attività dello Spoke 8 del progetto VITALITY, finanziato dal PNRR – M4C2, Investimento 1.5. L’evento mira a promuovere la...
Vitality (Spoke 8) – Presentazione delle Attrezzature Scientifiche
Un evento dedicato alla presentazione delle principali attrezzature scientifiche acquisite o impiegate nell’ambito dello Spoke 8 del progetto VITALITY, finanziato dal PNRR – Missione 4, Componente 2, Investimento 1.5. L’incontro si configura come un’occasione di...
Conferenza Stampa – Presentazione del Bando a Cascata dello Spoke 8 – Vitality
L’Università degli Studi di Urbino Carlo Bo presenta pubblicamente il Bando a Cascata dello Spoke n. 8, nell’ambito dell’ecosistema dell’innovazione VITALITY – Innovazione, digitalizzazione e sostenibilità per l’economia diffusa nel Centro Italia, finanziato dal PNRR...
Kick-off Meeting Spoke 8 – Progetto Vitality
Il Kick-off Meeting dello Spoke 8 del progetto VITALITY rappresenta l’avvio ufficiale delle attività legate al PNRR – Missione 4, Componente 2, Investimento 1.5, nell’ambito della creazione di ecosistemi dell’innovazione per il trasferimento della ricerca verso...